Review: The Role of Cannabinoids on Esophageal Function-What We Know Thus Far

Review: The Role of Cannabinoids on Esophageal Function-What We Know Thus Far

Abstract

The endocannabinoid system (ECS) primarily consists of cannabinoid receptors (CBRs), endogenous ligands, and enzymes for endocannabinoid biosynthesis and inactivation. Although the presence of CBRs, both CB1 and CB2, as well as a third receptor (G-protein receptor 55 [GPR55]), has been established in the gastrointestinal (GI) tract, few studies have focused on the role of cannabinoids on esophageal function. To date, studies have shown their effect on GI motility, inflammation and immunity, intestinal and gastric acid secretion, nociception and emesis pathways, and appetite control. Given the varying and sometimes limited efficacy of current medical therapies for diseases of the esophagus, further understanding and investigation into the interplay of the ECS on esophageal health and disease may present new therapeutic modalities that may help advance current treatment options. In this brief review, the current understanding of the ECS role in various esophageal functions and disorders is presented.

Copyright © 2018 Elsevier B.V. All rights reserved.
PMID: 29098187 PMCID: PMC5665514 DOI: 10.1089/can.2017.0031

 

Source:Pubmed

Gotfried J1,2Kataria R1,2Schey R1,2.

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